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.hero-grid{display:grid;grid-template-columns:minmax(0,1.65fr) minmax(245px,1fr);gap:54px;align-items:center}.hero-grid h1{font-size:clamp(38px,4.6vw,60px)}.avatar{background:#173b48;border:1px solid #48606a;border-radius:8px;overflow:hidden;max-width:365px;color:white}.avatar img{width:100%;height:175px;display:block;object-fit:cover;object-position:center 40%}.avatar-body{padding:17px 20px}.avatar-label{font-size:10px;color:#a4e7db;text-transform:uppercase;letter-spacing:.14em;font-weight:750}.avatar blockquote{margin:9px 0 14px;font-size:14px;line-height:1.5}.avatar-control{padding:7px 10px;border:1px solid #657c84;background:transparent;color:#d6e2e5;border-radius:4px;font-size:11px;opacity:1}.avatar-note{font-size:10px;color:#b9cbd0;line-height:1.4;margin:8px 0 0}.subhero .avatar{margin-left:auto}.subhero{padding:38px 0 42px}.subhero h1{font-size:clamp(34px,4vw,50px)}.subhero .lead{font-size:17px}.page-body{min-height:440px}.role{font-size:12px;color:var(--muted);text-transform:uppercase;letter-spacing:.1em}.story-photo{width:100%;height:270px;object-fit:cover;object-position:center 35%;border-radius:5px}.story-img{margin:0}.story-img figcaption{font-size:10px;color:var(--muted);margin-top:5px}.tools-filter{padding:12px 14px;background:white;border:1px solid var(--line);border-radius:5px;width:100%;max-width:460px}.resource{padding:22px 0;border-bottom:1px solid var(--line)}.resource h3{margin-top:5px}.resource a{font-size:13px}.resource .tag{margin-right:8px}.grid2{display:grid;grid-template-columns:1fr 1fr;gap:22px}.quote{font-size:23px;line-height:1.4;max-width:720px}.versions{display:grid;gap:12px}.version{background:#f4f7f5;border:1px solid var(--line);padding:15px 18px;border-radius:4px}.version strong{display:block}.source-note{font-size:12px;color:var(--muted)}.trace{margin:14px 0;padding:17px;background:#e8f0ec;border-left:3px solid var(--teal);font-size:13px;line-height:1.7}.skip{position:fixed;top:-80px;left:10px;background:white;color:var(--navy);padding:10px;z-index:10}.skip:focus{top:10px}.notice a{font-weight:650}.nav-group{display:flex;gap:20px}.hello{margin:0}.noscript{padding:20px;background:#f9ebc9}.compact-title{font-size:26px}.cta-strip{display:flex;gap:30px;justify-content:space-between;align-items:center;padding:28px;background:#e9f1ed;border-radius:6px}.cta-strip h3{margin:0}.inquiry textarea{min-height:170px}.qa-hint{font-size:11px;color:#52666c}.welcome-caption{font-size:12px;margin:0 0 16px;color:#a4e7db}.page-title:focus{outline:none}body.route-evidence .hero-grid,body.route-tools .hero-grid{align-items:start} @media(max-width:850px){.hero-grid{grid-template-columns:1.4fr 1fr;gap:28px}.avatar img{height:145px}.avatar-body{padding:14px}.hero{padding-top:32px}.hero-grid h1{font-size:43px}nav{gap:14px}.logo{font-size:14px}} @media(max-width:650px){.hero-grid{display:flex;flex-direction:column;align-items:stretch;gap:25px}.hero-grid .avatar{order:-1}.hero-grid h1{font-size:41px}.hero .lead{font-size:17px;margin-bottom:24px}.avatar{max-width:none;display:grid;grid-template-columns:110px 1fr}.avatar img{height:100%;min-height:185px;object-fit:cover;object-position:50% 35%}.avatar blockquote{font-size:13px}.avatar-body{padding:15px}.avatar-note{font-size:10px}.avatar-control{font-size:10px}.subhero .avatar{margin-left:0}.grid2{grid-template-columns:1fr}.cta-strip{display:block}.cta-strip .action{margin-top:16px}.story-photo{height:240px}nav{flex-wrap:wrap;gap:14px 18px}.header{gap:18px}.wrap{width:calc(100% - 32px)}.steps{gap:12px}.step b{font-size:16px}.step{gap:7px}.section{padding:38px 0}h2{font-size:30px}}
.patient-index{background:#d9eee5;border-bottom:1px solid #b0d0c4;padding:17px 0}.patient-index .wrap{display:flex;align-items:center;gap:12px;flex-wrap:wrap}.patient-index span{font-size:10px;letter-spacing:.1em;text-transform:uppercase;font-weight:800;color:#296254;margin-right:5px}.patient-index button{border:1px solid #86b3a4;background:#eef9f3;color:#184e42;border-radius:20px;font-size:12px;padding:8px 13px;font-weight:600}.patient-index button:hover{background:#c8e8db}.patient-lead{font-size:21px;line-height:1.55;color:#17453f}.learning-card{background:#e0eee8;border:1px solid #bed8cd;border-top:4px solid #409b86;border-radius:7px;padding:24px}.learning-card p{font-size:15px}.learning-card .source-note{font-size:12px}.learning-card.complementary{background:#e7edf4;border-color:#b3c8d8;border-top-color:#698da9}.patient-band{background:#d8eae3}.ask-line{font-size:14px;border-left:3px solid #18927c;padding:12px 15px;background:#ffffff70;margin:18px 0}.care-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:18px;margin:27px 0}.care-card{border:1px solid #b1d1c3;border-radius:7px;background:#e1f0e7;padding:23px;display:flex;flex-direction:column}.care-card h3{font-size:24px;line-height:1.2;margin:18px 0 12px}.care-card p{font-size:14px}.care-card .source-note{font-size:11px;margin-top:auto}.care-card .care-label{font-size:10px;letter-spacing:.09em;font-weight:800;color:#125840}.care-card.biomarker{background:#f5ead1;border-color:#dcc08d}.care-card.biomarker .care-label{color:#73521f}.care-card.biomarker .ask-line{border-color:#b08238}.care-card.research{background:#e8e5f4;border-color:#c3b9dc}.care-card.research .care-label{color:#58447d}.care-card.research .ask-line{border-color:#947fb8}.trial-strip{display:grid;grid-template-columns:1fr auto;gap:30px;align-items:center;background:#173e46;color:white;border-radius:6px;padding:25px}.trial-strip p{font-size:14px;max-width:730px;color:#dbebe8}.trial-strip h3{margin-top:0}.trial-strip .action{white-space:nowrap}.patient-video{background:#13363f;color:#fff}.patient-video .grid2{grid-template-columns:1.1fr 1fr;align-items:center}.patient-video h2{font-size:38px}.patient-video p{color:#c7ddda}.patient-video .kicker{color:#a4e7db}.patient-video video{width:100%;border-radius:8px;background:#08242b}.video-note{font-size:12px;color:#a8c9c2!important}.patient-video details{background:#1d4750;border-color:#437179}.patient-video details p{color:#cee1dc}.patient-video a{color:#c0f2df}.patient-video .video-status{background:#315960;padding:24px;border-radius:8px;border:1px solid #658e93}#patient-basics,#patient-samples,#patient-options,#patient-first-month,#patient-caregivers{scroll-margin-top:20px}@media(max-width:850px){.care-grid{grid-template-columns:1fr}.care-card{padding:25px}.care-card h3{margin:12px 0}.trial-strip{grid-template-columns:1fr;gap:14px}.trial-strip .action{width:fit-content}.patient-video .grid2{grid-template-columns:1fr}}@media(max-width:650px){.patient-index .wrap{gap:8px}.patient-index span{width:100%}.patient-index button{font-size:11px;padding:8px 10px}.patient-lead{font-size:19px}.learning-card{padding:21px}.patient-video h2{font-size:31px}}

/* Patient-first review: stronger navigation and content emphasis. */
:root{--cream:#edf6f3;--teal:#087d72}
header{border-bottom:1px solid #2c5960;padding:22px 0}nav{gap:9px}nav a{border:1px solid #3a626b;border-radius:6px;padding:12px 17px;color:#e0f1ef;font-size:12px;font-weight:650;transition:background .15s,color .15s}nav a:hover{background:#214d57}nav a[aria-current=page]{background:#a4e7db;border-color:#a4e7db;color:#092c34;text-decoration:none;box-shadow:0 3px 0 #56b8a9}.hero,.subhero{background:radial-gradient(ellipse at 20% 0%,#1c5159 0%,#0c2430 69%)}.hero .kicker{display:inline-block;border-radius:4px;background:#a4e7db;color:#123e43;padding:6px 10px;font-size:10px;letter-spacing:.13em}.headline-highlight{color:#a4e7db}.hero-grid h1{font-size:clamp(38px,4.6vw,60px)}.avatar{border:1px solid #5d9d9c;box-shadow:0 9px 24px #04181f35}.avatar-label{color:#f2d18d}.page-body{background:#edf6f3}.question{margin:12px 0;padding:17px 18px;border:1px solid #bbd9cf;border-left:4px solid #0c8f80;background:#fafffd;border-radius:5px;box-shadow:0 3px 0 #dbece6}.question b{color:#0d504e}.question span{margin-top:0}.question:has(input:checked){background:#e0f2e9;border-left-color:#008675}.action{background:#087d72;border-color:#087d72;color:#fff}.action:hover{background:#06665e;border-color:#06665e}.action.outline{background:#d7eee5;color:#17483f;border-color:#8ebfb0}.box{border-top:4px solid #459c8c;background:#e1efe9}.notice{background:#f3e7cd;border-color:#b88228;color:#584522}.fact{border-left:4px solid #55aa99;padding:18px 22px;background:#e4f0eb;margin:12px 0;border-radius:5px}.fact .kicker{color:#0d645b}.tag{color:#165f57}.resource{border-left:4px solid #71af9f;padding:18px 21px;margin:14px 0;background:#e1eee8;border-radius:5px}.resource .tag{display:inline-block;background:#c2e3d5;color:#15574d;padding:4px 7px;border-radius:4px}.footer-links{display:flex;gap:18px;flex-wrap:wrap;font-size:12px}.footer-links a{font-weight:600}.inquiry textarea{display:block;width:100%;margin:14px 0;padding:14px;border:1px solid #9fbfb4;background:#f9fffc;color:#23493e;resize:vertical}.route-evidence .hero .kicker{background:#d3d4f1;color:#2e3559}.route-pilot .hero .kicker{background:#f0d49b;color:#55401b}.route-pilot nav a[aria-current=page]{background:#f0d49b;border-color:#f0d49b;box-shadow:0 3px 0 #bd9b5d}.route-evidence nav a[aria-current=page]{background:#d3d4f1;border-color:#d3d4f1;box-shadow:0 3px 0 #929ac9}
@media(max-width:650px){header{padding:18px 0}.header{gap:18px}nav{gap:8px;display:grid;grid-template-columns:1fr 1fr;align-items:stretch}nav a{font-size:11px;padding:11px 10px;text-align:center;display:flex;justify-content:center;align-items:center}nav a:last-child{grid-column:1 / -1}.hero-grid h1{font-size:42px}.question{padding:16px 14px}.footer-links{gap:13px}.avatar{max-width:100%}}

/* Vaccine guide: short overview, optional depth, no change to other sections. */
#patient-vaccines{scroll-margin-top:20px;background:#e7edf4;border-top:1px solid #bccdd5}.vaccine-overview{margin:24px 0;align-items:stretch}.patient-vaccines .vaccine-overview h3{margin-top:0}.patient-vaccines details{border-radius:6px;border-color:#b5c9ce;background:#f9fcfb}.patient-vaccines details[open]>summary{padding-bottom:12px;border-bottom:1px solid #c7d7d9;margin-bottom:16px}.patient-vaccines .vaccine-family>summary span{display:block;margin-top:5px;font-size:12px;font-weight:400;color:#536a72}.patient-vaccines .vaccine-program{margin:12px 0;background:white;border-left:4px solid #71a99c}.patient-vaccines .vaccine-program p{max-width:950px}.patient-vaccines .source-note{font-size:12px;line-height:1.6;color:#536a72}.vaccine-guide-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:24px}.vaccine-guide-grid h3{font-size:17px}.vaccine-reviewed{margin:22px 0}.patient-vaccines .trial-strip{margin-top:24px}@media(max-width:850px){.vaccine-guide-grid{grid-template-columns:1fr;gap:8px}.patient-vaccines details{padding:17px 16px}.patient-vaccines .vaccine-program{padding:16px 13px}}

/* For Patients: approved welcome film first, all opening text retained. */
.patient-welcome{padding:40px 0;background:#13363f}.patient-welcome-grid{display:grid;grid-template-columns:minmax(0,1.1fr) minmax(0,1fr);gap:40px;align-items:start}.patient-welcome-film{min-width:0}.patient-welcome-film video{display:block;width:100%;height:auto;aspect-ratio:4/3;object-fit:contain;border-radius:12px;background:#13363f}.patient-welcome-copy{min-width:0}.patient-welcome-copy h1{font-size:clamp(32px,3.1vw,46px);line-height:1.1;margin:18px 0}.patient-welcome-copy .lead{font-size:17px;line-height:1.5;margin-bottom:28px}.patient-welcome-message blockquote{font-size:17px;line-height:1.5;margin:16px 0 20px}.patient-welcome-message .avatar-note{font-size:13px}.patient-welcome-message .avatar-control{padding:12px 16px}@media(max-width:800px){.patient-welcome{padding:24px 0 32px}.patient-welcome-grid{grid-template-columns:1fr;gap:28px}.patient-welcome-copy h1{font-size:36px}}

.patient-welcome-film h1{font-size:clamp(30px,3vw,42px);line-height:1.13;margin:0 0 24px}.welcome-context-title{font-size:28px;line-height:1.2;margin:20px 0 16px}.patient-welcome-copy .lead{margin-bottom:28px}@media(max-width:800px){.patient-welcome-film h1{font-size:32px}.welcome-context-title{font-size:26px}}

/* Concise For Patients journey; full evidence remains expandable. */
.patient-index-simple span{color:#73521f;background:#f9ebc9;padding:7px 10px;border-radius:6px}.patient-step{padding:40px 0;border-bottom:1px solid #d5dfdc}.patient-step .step-copy{max-width:820px}.patient-step h2{font-size:clamp(28px,3vw,38px);margin:12px 0 16px}.patient-step .step-copy>p{font-size:19px;line-height:1.55}.patient-step .step-question{padding:16px 20px;background:#e9f1ed;border-radius:10px}.patient-step .patient-safety{max-width:900px;padding:16px 20px;background:#f9ebc9;border-left:4px solid #e4ae43;border-radius:6px}.patient-step .kicker{color:#73521f}#patient-start{background:#f9ebc9}#patient-start .kicker{color:#73521f}.patient-more{margin:16px 0 0;border:1px solid #c5d8dc;border-radius:10px;background:#fff}.patient-more>summary{padding:18px 20px;font-weight:700;cursor:pointer}.patient-more-content>.section{padding:24px 0}.patient-more-content .wrap{width:auto;max-width:none;margin:0 20px}.patient-more-content .section .wrap{padding:0}@media(max-width:700px){.patient-step{padding:28px 0}.patient-step .step-copy>p{font-size:17px}.patient-more-content .wrap{margin:0 12px}}

.patient-education-notice{background:#f4ebd7;color:#16323d;padding:13px 0;border-bottom:1px solid #d1bc92;font-size:14px;line-height:1.5}.patient-education-notice .wrap{max-width:1200px}

.patient-step[hidden]{display:none!important}.patient-index-simple [role="tab"]{white-space:normal}.patient-index-simple [role="tab"][aria-selected="true"]{background:#13363f;color:#fff;border-color:#13363f;box-shadow:inset 0 -3px 0 #e4ae43}.patient-index-simple [role="tab"]:focus-visible,.topic-return button:focus-visible{outline:3px solid #e4ae43;outline-offset:3px}.topic-return{margin-top:28px}.patient-index-simple .wrap{flex-wrap:wrap;gap:8px}@media(max-width:700px){.patient-index-simple [role="tab"]{flex:1 1 42%;padding:12px 10px;min-height:48px}.patient-index-simple span{flex-basis:100%;text-align:center}}

.topic-quick-return{position:fixed;bottom:16px;left:16px;right:auto;z-index:30;background:#13363f;color:white;border:2px solid #e4ae43;border-radius:24px;padding:12px 18px;font:inherit;font-weight:700;box-shadow:0 3px 12px #0003;cursor:pointer}.topic-quick-return[hidden]{display:none}.patient-step{padding-bottom:80px}

/* Pilot hero shares the For Patients layout without changing that page. */
.pilot-welcome .pilot-placeholder{aspect-ratio:4/3;border:1px solid #5d9d9c;border-radius:12px;background:linear-gradient(145deg,#1c5159,#0c2430);display:flex;flex-direction:column;align-items:center;justify-content:center;text-align:center;padding:28px;gap:14px;color:#c7ddda}.pilot-placeholder strong{font-size:24px;color:#fff}.pilot-placeholder .placeholder-label{font-size:11px;letter-spacing:.12em;text-transform:uppercase;color:#a4e7db}.pilot-placeholder p{font-size:15px;max-width:310px;margin:0}.pilot-welcome .pilot-metrics{border-top:1px solid #4d7377;padding-top:20px;margin-top:20px;line-height:1.65;color:#c7ddda}.pilot-welcome .pilot-metrics b{color:#fff}.pilot-design-note{padding:24px 0;background:#f4ebd7;color:#16323d}.pilot-design-note p{margin:0;font-size:14px;line-height:1.6}.route-pilot nav a[aria-current=page]{background:#a4e7db;border-color:#a4e7db;box-shadow:0 3px 0 #56b8a9}.pilot-welcome.hero .kicker{background:#a4e7db;color:#123e43}

.pilot-welcome .patient-welcome-film h1{font-size:clamp(25px,2.65vw,36px);margin-bottom:16px;line-height:1.15}@media(min-width:1000px){.pilot-welcome .patient-welcome-film h1{white-space:nowrap}}

/* Investors and Rafael GBM Case retain the existing shared header and avatar. */
.avatar-placeholder-label{position:absolute;right:0;top:0;bottom:0;width:52%;padding:18% 7% 10% 2%;background:#15363e;color:white;display:flex;flex-direction:column;gap:12px}.avatar-placeholder-label span{text-transform:uppercase;letter-spacing:.1em;font-size:9px;color:#a4e7db}.avatar-placeholder-label b{font-size:clamp(15px,1.9vw,24px);line-height:1.25;font-weight:650}.message-pending{z-index:1}@media(max-width:600px){.avatar-placeholder-label b{font-size:20px}}
.review-avatar{position:relative;border:1px solid #48636b;border-radius:8px;overflow:hidden;background:#12363f}.review-avatar img{display:block;width:100%;height:auto;aspect-ratio:16/9;object-fit:cover}.message-pending{position:absolute;left:0;right:0;bottom:0;padding:12px 16px;background:linear-gradient(transparent,rgba(6,25,34,.93));display:flex;align-items:center;gap:10px;font-size:12px;font-weight:650;color:#fff}.pending-icon{font-size:28px;line-height:1}.review-placeholder{padding:18px 20px;border:1px dashed #68868c;border-radius:5px;background:#ffffff05;margin-top:25px;color:#c8dfe0;font-size:13px}.review-placeholder b{color:#a4e7db}.review-placeholder p{font-size:12px;margin-bottom:0}.review-context{background:#e8eee8;border-bottom:1px solid #c6d7d0;padding:17px 0;color:#405c61;font-size:13px}.review-context p{margin:8px 0;max-width:1050px}.review-context a{font-weight:650}.reference-frame{display:block;width:100%;height:3000px;border:0;background:#f6f5f0}.case-review-boundary{padding:12px 16px;background:#f6f5f0}.case-review-boundary summary{font-size:12px}.case-review-boundary p{font-size:12px}.supporting-library{padding-bottom:35px}.supporting-library .wrap{width:100%}.supporting-library .section{padding:16px 0}.header nav{flex-wrap:wrap;justify-content:flex-end;gap:18px}.header nav a{white-space:nowrap}@media(max-width:700px){.header{flex-direction:column;align-items:flex-start}.header nav{justify-content:flex-start;gap:10px 18px}.review-context{font-size:12px}.review-placeholder{margin-top:20px}.review-welcome .patient-welcome-grid{gap:25px}}
@media(max-width:600px){header nav a:last-child{grid-column:auto}.avatar-placeholder-label{padding-top:12%;gap:8px}.avatar-placeholder-label b{font-size:18px}.message-pending{font-size:10px;padding:8px 12px}.pending-icon{font-size:22px}}

/* Investor planning estimates: scoped to the investor page. */
[data-page="investors"] .investor-funding{border-left:3px solid #a4e7db;padding:3px 0 3px 18px;margin-top:22px}[data-page="investors"] .investor-funding>span{display:block;font-size:11px;font-weight:700;letter-spacing:.11em;text-transform:uppercase;color:#a4e7db}[data-page="investors"] .investor-funding strong{display:block;font-size:36px;letter-spacing:-.03em;color:#fff;line-height:1.3;margin:5px 0}[data-page="investors"] .investor-funding p{font-size:12px;line-height:1.6;max-width:410px;margin:7px 0;color:#c7dce0}[data-page="investors"] .investor-opportunity{padding:44px 0 25px}[data-page="investors"] .investor-section-intro{display:flex;align-items:flex-start;justify-content:space-between;gap:28px;margin-bottom:24px}[data-page="investors"] .investor-section-intro h2{margin:8px 0 12px}[data-page="investors"] .investor-section-intro p{max-width:760px;margin:0;color:var(--muted);font-size:15px}[data-page="investors"] .investor-estimate-badge{flex-shrink:0;border:1px solid #c8d7cf;background:#e9f0e9;border-radius:5px;font-size:11px;line-height:1.7;color:#52675a;padding:12px 15px;margin-top:5px}[data-page="investors"] .investor-estimate-badge b{font-size:11px;color:#2b4f47}[data-page="investors"] .investor-access-grid{display:grid;grid-template-columns:minmax(0,1.7fr) minmax(250px,1fr);gap:22px;align-items:stretch}[data-page="investors"] .investor-access-chart{margin:0;background:#fff;border:1px solid var(--line);border-radius:7px;padding:25px}[data-page="investors"] .investor-access-chart figcaption{padding-bottom:21px;border-bottom:1px solid #e0e7e2}[data-page="investors"] .investor-access-chart figcaption b{display:block;font-size:16px}[data-page="investors"] .investor-access-chart figcaption>span{display:block;color:var(--muted);font-size:12px;line-height:1.6;margin-top:5px}[data-page="investors"] .investor-chart-row{margin-top:20px}[data-page="investors"] .investor-row-label{display:flex;gap:12px;justify-content:space-between;align-items:baseline;font-size:14px}[data-page="investors"] .investor-row-label>b{font-size:20px;white-space:nowrap;font-variant-numeric:tabular-nums;line-height:1.3}[data-page="investors"] .investor-row-label small{font-size:12px;font-weight:600;color:#526a70;display:inline-block;text-align:right;min-width:48px}[data-page="investors"] .investor-track{height:9px;background:#e9eeea;border-radius:10px;overflow:hidden;margin-top:7px}[data-page="investors"] .investor-track>span{height:100%;display:block;border-radius:10px;background:#1c5362}[data-page="investors"] .investor-chart-row:nth-child(2) .investor-track>span{background:#267983}[data-page="investors"] .investor-chart-row:nth-child(3) .investor-track>span{background:#188e89}[data-page="investors"] .investor-chart-row:nth-child(4) .investor-track>span{background:#51a5a0}[data-page="investors"] .investor-endpoint .investor-track>span{background:#a76d20}[data-page="investors"] .investor-chart-row p{font-size:11px;color:var(--muted);margin:5px 0 0;line-height:1.5}[data-page="investors"] .investor-chart-limits{font-size:12px;line-height:1.7;color:#4a6269;border-top:1px solid #e0e7e2;margin:22px 0 0;padding-top:16px}[data-page="investors"] .investor-access-aside{display:grid;gap:18px;align-content:start}[data-page="investors"] .investor-key-number{padding:24px;background:#123b47;color:#e3eeeb;border-radius:7px;border:1px solid #123b47}[data-page="investors"] .investor-key-number>span{font-size:10px;letter-spacing:.12em;text-transform:uppercase;font-weight:750;color:#b7d9d1}[data-page="investors"] .investor-key-number>strong{display:block;font-size:72px;letter-spacing:-.055em;color:#b3ead7;line-height:1.1;margin:12px 0}[data-page="investors"] .investor-key-number p{font-size:14px;line-height:1.65;margin:12px 0 0}[data-page="investors"] .investor-key-number .small{font-size:12px;color:#bfd2d3;border-top:1px solid #3a5e65;padding-top:15px;margin-top:17px}[data-page="investors"] .investor-public-study{padding:21px 22px;background:#e8eee8;border:1px solid #ccd9d0;border-radius:7px}[data-page="investors"] .investor-public-study h3{font-size:17px;margin:0 0 12px}[data-page="investors"] .investor-public-study p{font-size:13px;line-height:1.65;margin:0 0 12px}[data-page="investors"] .investor-public-study .small{font-size:12px;color:#4b6269}[data-page="investors"] .investor-public-study a{font-size:12px;font-weight:700}[data-page="investors"] .investor-source-details{margin-top:18px;padding:15px 20px;background:#fff}[data-page="investors"] .investor-source-details summary{font-size:13px}[data-page="investors"] .investor-source-details p{font-size:12px;line-height:1.7;color:var(--muted)}[data-page="investors"] .investor-test-plan{margin-top:30px;padding-top:28px;border-top:1px solid var(--line)}[data-page="investors"] .investor-test-heading h3{font-size:25px;margin:8px 0}[data-page="investors"] .investor-test-heading p{font-size:13px;color:var(--muted);margin:0 0 20px}[data-page="investors"] .investor-measures{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:18px}[data-page="investors"] .investor-measures article{padding:20px;border:1px solid var(--line);border-radius:5px;background:#fff}[data-page="investors"] .investor-measures article>span{font-size:11px;font-weight:800;color:#137d74}[data-page="investors"] .investor-measures h4{font-size:15px;margin:9px 0}[data-page="investors"] .investor-measures p{font-size:12px;color:var(--muted);line-height:1.7;margin:0}@media(max-width:760px){[data-page="investors"] .investor-section-intro{display:block}[data-page="investors"] .investor-estimate-badge{display:inline-block;margin-top:16px}[data-page="investors"] .investor-access-grid{grid-template-columns:1fr}[data-page="investors"] .investor-access-chart{padding:20px}[data-page="investors"] .investor-measures{grid-template-columns:1fr}[data-page="investors"] .investor-row-label{font-size:13px}[data-page="investors"] .investor-row-label>b{font-size:19px}[data-page="investors"] .investor-row-label small{min-width:43px;font-size:11px}[data-page="investors"] .investor-opportunity{padding-top:30px}}


/* Investor chapters: global context, national model, local access example. */
[data-page="investors"] .investor-chapter{padding:38px 0;border-bottom:1px solid var(--line)}[data-page="investors"] .investor-chapter-head{display:flex;gap:18px;align-items:center;margin-bottom:24px}[data-page="investors"] .investor-chapter-num{display:grid;place-items:center;flex:none;width:48px;height:48px;border-radius:50%;background:#163f4a;color:#d3eee5;font-size:17px;font-weight:750;font-variant-numeric:tabular-nums}[data-page="investors"] .investor-chapter-head .kicker{font-size:11px;letter-spacing:.12em}[data-page="investors"] .investor-chapter-head h2{font-size:29px;margin:5px 0 0;line-height:1.2}[data-page="investors"] .investor-chapter-lead{color:var(--muted);max-width:900px;margin:0 0 22px;font-size:15px}[data-page="investors"] .investor-stat-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:17px}[data-page="investors"] .investor-stat-grid.four{grid-template-columns:repeat(4,minmax(0,1fr))}[data-page="investors"] .investor-stat{border:1px solid var(--line);border-radius:7px;background:#fff;padding:22px}[data-page="investors"] .investor-stat>span{display:block;color:#38645f;font-size:11px;font-weight:750;letter-spacing:.07em;text-transform:uppercase}[data-page="investors"] .investor-stat strong{display:block;color:#153e49;font-size:31px;line-height:1.2;letter-spacing:-.025em;margin:13px 0}[data-page="investors"] .investor-stat p{font-size:12px;line-height:1.7;color:var(--muted);margin:0}[data-page="investors"] .investor-stat .period{font-size:10px;font-weight:700;text-transform:uppercase;letter-spacing:.04em;margin-top:13px;color:#62766e}[data-page="investors"] .investor-chapter-note{font-size:12px;line-height:1.75;color:#4a6269;margin:18px 0 0}[data-page="investors"] .investor-formula{background:#e8efea;padding:18px 22px;border-radius:5px;color:#234f51;font-size:14px;font-weight:650;text-align:center;margin:20px 0 0}.investor-math-note{display:block;font-size:12px;line-height:1.65;font-weight:400;margin-top:10px;color:#4a6269}[data-page="investors"] .investor-test-plan{margin-top:38px;padding-top:32px}[data-page="investors"] .investor-thesis{margin:22px 0 0;padding:22px;border-left:3px solid #70b7a7;background:#e8f0e9;border-radius:0 5px 5px 0}[data-page="investors"] .investor-thesis h4{font-size:19px;margin:0 0 9px}[data-page="investors"] .investor-thesis p{font-size:13px;line-height:1.75;margin:0;color:#355a60}
@media(max-width:900px){[data-page="investors"] .investor-stat-grid.four{grid-template-columns:repeat(2,minmax(0,1fr))}}@media(max-width:760px){[data-page="investors"] .investor-stat-grid{grid-template-columns:1fr}[data-page="investors"] .investor-chapter{padding:28px 0}[data-page="investors"] .investor-chapter-head{gap:13px}[data-page="investors"] .investor-chapter-head h2{font-size:25px}[data-page="investors"] .investor-stat strong{font-size:28px}[data-page="investors"] .investor-stat{padding:19px}[data-page="investors"] .investor-formula{text-align:left;font-size:13px}}

[data-page="investors"] .investor-policy{margin-top:34px;margin-bottom:4px;border:1px solid #9ebeb4;border-top:4px solid #287f73;border-radius:7px;background:#edf3ec;padding:27px}[data-page="investors"] .investor-policy>h2{font-size:28px;line-height:1.2;margin:9px 0 12px}[data-page="investors"] .investor-policy-lead{font-size:14px;color:#42636a;line-height:1.7;margin:0 0 21px;max-width:920px}[data-page="investors"] .investor-policy-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:16px}[data-page="investors"] .investor-policy-grid article{background:#fff;border:1px solid #cfddd4;border-radius:5px;padding:21px}[data-page="investors"] .investor-policy-grid article>span{font-size:10px;letter-spacing:.09em;text-transform:uppercase;font-weight:750;color:#28786e}[data-page="investors"] .investor-policy-grid h3{font-size:18px;margin:9px 0 12px;line-height:1.3}[data-page="investors"] .investor-policy-grid p{font-size:12px;line-height:1.7;color:#4b6269;margin:0 0 13px}[data-page="investors"] .investor-policy-grid a{font-size:11px;font-weight:700}[data-page="investors"] .investor-policy-risk{margin-top:19px;padding:16px 19px;background:#f7f2e6;border:1px solid #ded0ae;border-radius:5px;font-size:12px;color:#665733;line-height:1.7}[data-page="investors"] .investor-policy-risk b{color:#594824}[data-page="investors"] .investor-policy-risk p{margin:5px 0 0}@media(max-width:760px){[data-page="investors"] .investor-policy{padding:20px;margin-top:26px}[data-page="investors"] .investor-policy>h2{font-size:25px}[data-page="investors"] .investor-policy-grid{grid-template-columns:1fr}[data-page="investors"] .investor-policy-grid article{padding:19px}}
.standard-protocol{list-style:none;padding:0;margin:24px 0;counter-reset:care-step;display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:12px}.standard-protocol li{counter-increment:care-step;background:#e1f0e7;border:1px solid #b1d1c3;border-radius:9px;padding:18px;position:relative}.standard-protocol li::before{content:counter(care-step,decimal-leading-zero);display:block;font-size:12px;letter-spacing:.1em;color:#296254;font-weight:800;margin-bottom:10px}.standard-protocol b{display:block;font-size:17px;line-height:1.3;color:#17453f}.standard-protocol span{display:block;font-size:14px;line-height:1.5;margin-top:9px}.standard-links{display:flex;align-items:center;flex-wrap:wrap;gap:14px 20px;margin:23px 0 30px}.standard-links>a:not(.action){font-size:14px;font-weight:600}#patient-care-step .step-copy>p.source-note,#patient-care-step .step-copy>p.small{font-size:13px;line-height:1.5}@media(max-width:650px){.standard-protocol{grid-template-columns:1fr}.standard-protocol li{padding:17px 20px}.standard-links{align-items:flex-start;flex-direction:column}.standard-links .action{white-space:normal;text-align:center}}
.investor-chart-limits p{margin:0 0 9px}.investor-chart-limits p:last-child{margin-bottom:0}.investor-cohort-row{border-top:1px solid var(--line);padding-top:13px;margin-top:13px}.investor-cohort-row>b{display:block;font-size:14px;color:#234f51}.investor-cohort-row p{margin:6px 0}.investor-brief-link{display:block;font-weight:750;font-size:13px;border-top:1px solid var(--line);padding-top:16px;margin-top:18px}.investor-brief-caption{font-size:11px!important;line-height:1.6!important}.investor-cost-section{background:#edf5f1;padding-top:0}.investor-cost-panel{border:1px solid #d0ded5;border-radius:10px;background:#f5f8f3;padding:28px}.investor-cost-header{display:flex;justify-content:space-between;align-items:flex-end;gap:20px;margin-bottom:25px}.investor-cost-header h2{font-size:32px;margin-bottom:0}.investor-cost-badge{border:1px solid #cbdcd5;border-radius:30px;padding:7px 13px;font-size:10px;font-weight:750;letter-spacing:.09em;color:#38645f;text-transform:uppercase;white-space:nowrap}.investor-cost-layout{display:grid;grid-template-columns:minmax(0,1.9fr) minmax(270px,1fr);gap:22px;align-items:start}.investor-cost-chart{margin:0;border:1px solid #d5dfdc;border-radius:7px;padding:22px;background:#fff}.investor-cost-row{margin-bottom:23px}.investor-cost-label{display:flex;justify-content:space-between;align-items:flex-start;gap:16px}.investor-cost-label b{font-size:14px;line-height:1.35}.investor-cost-label strong{font-size:16px;white-space:nowrap}.investor-cost-label p{font-size:12px;color:#536a72;margin:3px 0 0}.investor-cost-track{height:9px;border-radius:12px;background:#e5ebe7;margin-top:10px;overflow:hidden}.investor-cost-track span{display:block;height:100%;min-width:7px;border-radius:12px}.investor-cost-chart figcaption{border-top:1px solid #d5dfdc;padding-top:15px;font-size:12px;line-height:1.7;color:#536a72}.investor-cost-aside{display:grid;gap:14px}.investor-cost-note,.investor-book-card{padding:19px;border:1px solid #cddbd4;border-radius:7px;background:#eef3ed}.investor-cost-note h3,.investor-book-card h3{font-size:17px;margin:0 0 9px;line-height:1.3}.investor-cost-note p,.investor-book-card p{font-size:12px;line-height:1.7;margin:0}.investor-cost-warning{background:#f7eceb;border-color:#e5c9c5}.investor-cost-warning h3{color:#8d4147}.investor-book-card{background:#e4eee6;border-color:#aec8b6;scroll-margin-top:24px}.investor-book-card .kicker{font-size:9px;margin-bottom:8px}.investor-book-card h3{font-size:22px;color:#234f51}.investor-book-byline{font-size:11px!important;font-weight:700;color:#536a72;margin-bottom:12px!important}.investor-book-boundary{font-size:11px!important;border-top:1px solid #c3d7c9;padding-top:12px;margin-top:13px!important}.investor-book-card a{display:block;font-size:12px;font-weight:700;margin-top:13px;color:#235f50}.investor-book-card .investor-book-faq{font-size:10px;font-weight:400;margin-top:8px}.investor-book-jump{display:block;background:transparent;border:0;padding:0;color:#286d58;text-decoration:underline;text-underline-offset:3px;font-size:11px;margin-top:6px;text-align:left}@media(max-width:850px){.investor-cost-header{display:block}.investor-cost-badge{display:inline-block;margin-top:17px}.investor-cost-layout{grid-template-columns:1fr}.investor-cost-header h2{font-size:28px}}@media(max-width:520px){.investor-cost-panel{padding:18px}.investor-cost-chart{padding:16px}.investor-cost-label b{font-size:13px}.investor-cost-label strong{font-size:14px}.investor-cost-label p{font-size:11px}.investor-cost-note,.investor-book-card{padding:17px}}.investor-cost-label strong{font-size:24px;line-height:1.2;letter-spacing:-.025em;font-variant-numeric:tabular-nums}.investor-cost-badge{white-space:normal}@media(max-width:520px){.investor-cost-label strong{font-size:21px}}
/* Shared page-title scale across Patients, Pilot, Investors, and Rafael GBM Case. */
.patient-welcome .patient-welcome-film .page-title{font-family:inherit;font-size:clamp(2rem,3vw,2.625rem);font-weight:750;line-height:1.13;letter-spacing:-.04em;margin:0 0 24px;max-width:none;white-space:normal;overflow-wrap:normal}

.staging-notice{background:#fff2cc;color:#382e12;text-align:center;padding:8px 18px;font-size:13px}.patient-welcome-film>video{display:block;width:100%;border-radius:18px;background:#102e3d;aspect-ratio:16/9}